December 16, 2025 by Alipheron

Addressing two big bottlenecks of 2025: rigid workflows and complex biology

As we look back on 2025, Drug Discovery hit two major walls.

First, the “Scale Wall”: You had one workflow for small, off-the-shelf catalogs and a completely different, heavier pipeline for ultra-large spaces. Second, the “Modality Wall”: Standard tools struggled to handle the specific requirements of covalent binders, glues, and PROTACs without massive manual intervention.

For 2026, we are tearing down both walls.

We are introducing two major innovations to power your 2026 campaigns:

1️⃣ 𝗧𝗵𝗲 𝗔𝘁𝗹𝗮𝘀 𝗙𝗿𝗮𝗺𝗲𝘄𝗼𝗿𝗸: We are unifying the screening pipeline. You can now apply our blazingly-fast precise substructure and structure similarity search tool, 𝗛𝘆𝗽𝗲𝗿𝘀𝗽𝗮𝗰𝗲 𝗦𝗲𝗮𝗿𝗰𝗵 to any library. Whether you are screening a niche vendor catalog of 200k compounds or exploring our expanding 𝟲 𝗧𝗿𝗶𝗹𝗹𝗶𝗼𝗻 𝗰𝗵𝗲𝗺𝗶𝗰𝗮𝗹 𝘂𝗻𝗶𝘃𝗲𝗿𝘀𝗲, the workflow is seamless. One framework, any scale.

𝗟𝗲𝗮𝗿𝗻 𝗺𝗼𝗿𝗲: https://alipheron.com/products/atlas/

2️⃣ 𝗣𝗵𝗮𝗿𝗼𝘀-𝟯𝗗 𝗳𝗼𝗿 𝗖𝗼𝗺𝗽𝗹𝗲𝘅 𝗠𝗼𝗱𝗮𝗹𝗶𝘁𝗶𝗲𝘀: We have upgraded our 3D search engine to specifically tackle “undruggable” mechanisms. The new Pharos-3D gives you granular specification control suitable to tackle problems with 𝗖𝗼𝘃𝗮𝗹𝗲𝗻𝘁 𝗯𝗶𝗻𝗱𝗲𝗿𝘀, 𝗠𝗼𝗹𝗲𝗰𝘂𝗹𝗮𝗿 𝗚𝗹𝘂𝗲𝘀, 𝗮𝗻𝗱 𝗣𝗥𝗢𝗧𝗔𝗖𝘀.

We are fully launching in late January. But for CADD teams currently planning their 2026 targets, especially those working on protein degradation or covalent modifiers, we are opening an Early Access list today.

𝗟𝗶𝗻𝗸 𝘁𝗼 𝗪𝗮𝗶𝘁𝗹𝗶𝘀𝘁: https://alipheron.com/#waitlist

𝗦𝗰𝗮𝗹𝗲 𝘀𝗲𝗮𝗺𝗹𝗲𝘀𝘀𝗹𝘆. 𝗦𝗰𝗿𝗲𝗲𝗻 𝘀𝗽𝗲𝗰𝗶𝗳𝗶𝗰𝗮𝗹𝗹𝘆.